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Fontana L, Adelaiye RM, Rastelli AL, et al. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 2013;4(12):2451–61. https://pubmed.ncbi.nlm.nih.gov/24353195/

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Fontana L, Adelaiye RM, Rastelli AL, et al. Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget. 2013;4(12):2451–61. https://pubmed.ncbi.nlm.nih.gov/24353195/

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Rubio-Patiño C, Bossowski JP, De Donatis GM, et al. Low-protein diet induces IRE1a-dependent anticancer immunosurveillance. Cell Metab. 2018;27(4):828–42.e7. https://pubmed.ncbi.nlm.nih.gov/29551590/

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Orillion A, Damayanti NP, Shen L, et al. Dietary protein restriction reprograms tumor-associated macrophages and enhances immunotherapy. Clin Cancer Res. 2018;24(24):6383–95. https://pubmed.ncbi.nlm.nih.gov/30190370/

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Pili R, Fontana L. Low-protein diet in cancer: ready for prime time? Nat Rev Endocrinol. 2018;14(7):384–6. https://pubmed.ncbi.nlm.nih.gov/29765134/

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Gao X, Sanderson SM, Dai Z, et al. Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature. 2019;572(7769):397–401. https://pubmed.ncbi.nlm.nih.gov/31367041/

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Solon-Biet SM, McMahon AC, Ballard JWO, et al. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metab. 2014;19(3):418–30. https://pubmed.ncbi.nlm.nih.gov/24606899/

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Trepanowski JF, Canale RE, Marshall KE, Kabir MM, Bloomer RJ. Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. Nutr J. 2011;10:107. https://pubmed.ncbi.nlm.nih.gov/21981968/

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Pamplona R, Barja G. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim Biophys Acta. 2006;1757(5–6):496–508. https://pubmed.ncbi.nlm.nih.gov/16574059/

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McIsaac RS, Lewis KN, Gibney PA, Buffenstein R. From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span. Ann N Y Acad Sci. 2016;1363:155–70. https://pubmed.ncbi.nlm.nih.gov/26995762/

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Gorbunova V, Bozzella MJ, Seluanov A. Rodents for comparative aging studies: from mice to beavers. Age (Dordr). 2008;30(2–3):111–9. https://pubmed.ncbi.nlm.nih.gov/19424861/

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Zimmerman JA, Malloy V, Krajcik R, Orentreich N. Nutritional control of aging. Exp Gerontol. 2003;38(1–2):47–52. https://pubmed.ncbi.nlm.nih.gov/12543260/

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Swindell WR. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev. 2012;11(2):254–70. https://pubmed.ncbi.nlm.nih.gov/22210149/

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Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell. 2005;4(3):119–25. https://pubmed.ncbi.nlm.nih.gov/15924568/

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Yu D, Yang SE, Miller BR, et al. Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J. 2018;32(6):3471–82. https://pubmed.ncbi.nlm.nih.gov/29401631/

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Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell. 2005;4(3):119–25. https://pubmed.ncbi.nlm.nih.gov/15924568/

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Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell. 2005;4(3):119–25. https://pubmed.ncbi.nlm.nih.gov/15924568/

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Yu D, Yang SE, Miller BR, et al. Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. FASEB J. 2018;32(6):3471–82. https://pubmed.ncbi.nlm.nih.gov/29401631/

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Ruckenstuhl C, Netzberger C, Entfellner I, et al. Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification. PLoS Genet. 2014;10(5):e1004347. https://pubmed.ncbi.nlm.nih.gov/24785424/

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Sharma S, Dixon T, Jung S, et al. Dietary methionine restriction reduces inflammation independent of FGF21 action. Obesity (Silver Spring). 2019;27(8):1305–13. https://pubmed.ncbi.nlm.nih.gov/31207147/

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Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell. 2005;4(3):119–25. https://pubmed.ncbi.nlm.nih.gov/15924568/

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Brown-Borg HM, Rakoczy SG, Wonderlich JA, et al. Growth hormone signaling is necessary for lifespan extension by dietary methionine. Aging Cell. 2014;13(6):1019–27. https://pubmed.ncbi.nlm.nih.gov/25234161/

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Harper AE, Benevenga NJ, Wohlhueter RM. Effects of ingestion of disproportionate amounts of amino acids. Physiol Rev. 1970;50(3):428–558. https://pubmed.ncbi.nlm.nih.gov/4912906/

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López-Torres M, Barja G. Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction. Possible implications for humans. Biochim Biophys Acta. 2008;1780(11):1337–47. https://pubmed.ncbi.nlm.nih.gov/18252204/

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Mori N, Hirayama K. Long-term consumption of a methionine-supplemented diet increases iron and lipid peroxide levels in rat liver. J Nutr. 2000;130(9):2349–55. https://pubmed.ncbi.nlm.nih.gov/10958834/

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Hidiroglou N, Gilani GS, Long L, et al. The influence of dietary vitamin E, fat, and methionine on blood cholesterol profile, homocysteine levels, and oxidizability of low density lipoprotein in the gerbil. J Nutr Biochem. 2004;15(12):730–40. https://pubmed.ncbi.nlm.nih.gov/15607646/