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Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J. 2006;20(8):1064–73. https://pubmed.ncbi.nlm.nih.gov/16770005/

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Caro P, Gomez J, Sanchez I, et al. Effect of 40 % restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver. Biogerontology. 2009;10(5):579–92. https://pubmed.ncbi.nlm.nih.gov/19039676/

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Moskovitz J, Bar-Noy S, Williams WM, Requena J, Berlett BS, Stadtman ER. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A. 2001;98(23):12920–5. https://pubmed.ncbi.nlm.nih.gov/11606777/

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Pamplona R, Barja G. Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection. Biochim Biophys Acta. 2006;1757(5–6):496–508. https://pubmed.ncbi.nlm.nih.gov/16574059/

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Lushchak O, Strilbytska OM, Yurkevych I, Vaiserman AM, Storey KB. Implications of amino acid sensing and dietary protein to the aging process. Exp Gerontol. 2019;115:69–78. https://pubmed.ncbi.nlm.nih.gov/30502540/

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Ruan H, Tang XD, Chen ML, et al. High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proc Natl Acad Sci U S A. 2002;99(5):2748–53. https://pubmed.ncbi.nlm.nih.gov/11867705/

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Takauji Y, Wada T, Takeda A, et al. Restriction of protein synthesis abolishes senescence features at cellular and organismal levels. Sci Rep. 2016;6:18722. https://pubmed.ncbi.nlm.nih.gov/26729469/

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Green CL, Lamming DW, Fontana L. Molecular mechanisms of dietary restriction promoting health and longevity. Nat Rev Mol Cell Biol. 2022;23(1):56–73. https://pubmed.ncbi.nlm.nih.gov/34518687/

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Koziel R, Ruckenstuhl C, Albertini E, et al. Methionine restriction slows down senescence in human diploid fibroblasts. Aging Cell. 2014;13(6):1038–48. https://pubmed.ncbi.nlm.nih.gov/25273919/

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Brown-Borg HM, Buffenstein R. Cutting back on the essentials: can manipulating intake of specific amino acids modulate health and lifespan? Ageing Res Rev. 2017;39:87–95. https://pubmed.ncbi.nlm.nih.gov/27570078/

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Johnson JE, Johnson FB. Methionine restriction activates the retrograde response and confers both stress tolerance and lifespan extension to yeast, mouse and human cells. PLoS One. 2014;9(5):e97729. https://pubmed.ncbi.nlm.nih.gov/24830393/

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Agrawal V, Alpini SEJ, Stone EM, Frenkel EP, Frankel AE. Targeting methionine auxotrophy in cancer: discovery & exploration. Expert Opin Biol Ther. 2012;12(1):53–61. https://pubmed.ncbi.nlm.nih.gov/22171665/

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Han Q, Tan Y, Hoffman RM. Oral dosing of recombinant methioninase is associated with a 70 % drop in PSA in a patient with bone-metastatic prostate cancer and 50 % reduction in circulating methionine in a high-stage ovarian cancer patient. Anticancer Res. 2020;40(5):2813–9. https://pubmed.ncbi.nlm.nih.gov/32366428/

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Cavuoto P, Fenech MF. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev. 2012;38(6):726–36. https://pubmed.ncbi.nlm.nih.gov/22342103/

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Heilbronn LK, Panda S. Alternate-day fasting gets a safe bill of health. Cell Metab. 2019;30(3):411–3. https://pubmed.ncbi.nlm.nih.gov/31484053/

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Stekovic S, Hofer SJ, Tripolt N, et al. Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans. Cell Metab. 2019;30(3):462–76. https://pubmed.ncbi.nlm.nih.gov/31471173/

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McCarty MF, Barroso-Aranda J, Contreras F. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses. 2009;72(2):125–8. https://pubmed.ncbi.nlm.nih.gov/18789600/

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Kitada M, Ogura Y, Monno I, Koya D. The impact of dietary protein intake on longevity and metabolic health. EBioMedicine. 2019;43:632–40. https://pubmed.ncbi.nlm.nih.gov/30975545/

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Yamamoto J, Han Q, Simon M, Thomas D, Hoffman RM. Methionine restriction: ready for prime time in the cancer clinic? Anticancer Res. 2022;42(2):641–4. https://pubmed.ncbi.nlm.nih.gov/35093861/

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Product information: Hominex®-2. Abbott Laboratories Inc. Updated May 3, 2022.; https://www.abbottnutrition.com/our-products/hominex-2

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Yamamoto J, Han Q, Simon M, Thomas D, Hoffman RM. Methionine restriction: ready for prime time in the cancer clinic? Anticancer Res. 2022;42(2):641–4. https://pubmed.ncbi.nlm.nih.gov/35093861/

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McCarty MF, Barroso-Aranda J, Contreras F. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses. 2009;72(2):125–8. https://pubmed.ncbi.nlm.nih.gov/18789600/

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Agricultural Research Service, United States Department of Agriculture. Component search: methionine. FoodData Central. https://fdc.nal.usda.gov/fdc-app.html#/food-search?component=1215. Accessed January 25, 2023.; https://fdc.nal.usda.gov/fdc-app.html#/food-search?component=1215

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Gaudichon C, Calvez J. Determinants of amino acid bioavailability from ingested protein in relation to gut health. Curr Opin Clin Nutr Metab Care. 2021;24(1):55–61. https://pubmed.ncbi.nlm.nih.gov/33093304/

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McCarty MF, Barroso-Aranda J, Contreras F. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses. 2009;72(2):125–8. https://pubmed.ncbi.nlm.nih.gov/18789600/

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Cavuoto P, Fenech MF. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev. 2012;38(6):726–36. https://pubmed.ncbi.nlm.nih.gov/22342103/

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Cavuoto P, Fenech MF. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev. 2012;38(6):726–36. https://pubmed.ncbi.nlm.nih.gov/22342103/

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Krajcovicova-Kudlackova M, Babinska K, Valachovicova M. Health benefits and risks of plant proteins. Bratisl Lek Listy. 2005;106(6–7):231–4. https://pubmed.ncbi.nlm.nih.gov/16201743/

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Schmidt JA, Rinaldi S, Scalbert A, et al. Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort. Eur J Clin Nutr. 2016;70(3):306–12. https://pubmed.ncbi.nlm.nih.gov/26395436/

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Wu G, Han L, Shi Y, et al. Effect of different levels of dietary methionine restriction on relieving oxidative stress and behavioral deficits in middle-aged mice fed low-, medium-, or high-fat diet. J Funct Foods. 2020;65:103782. https://doi.org/10.1016/j.jff.2020.103782

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Trepanowski JF, Canale RE, Marshall KE, Kabir