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Tynkkynen J, Chouraki V, van der Lee SJ, et al. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer’s disease: a prospective study in eight cohorts. Alzheimers Dement. 2018;14(6):723–33. https://pubmed.ncbi.nlm.nih.gov/29519576/
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Le Couteur DG, Solon-Biet SM, Cogger VC, et al. Branched chain amino acids, aging and age-related health. Ageing Res Rev. 2020;64:101198. https://pubmed.ncbi.nlm.nih.gov/33132154/
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Xu B, Wang M, Pu L, Shu C, Li L, Han L. Association of dietary intake of branched-chain amino acids with long-term risks of CVD, cancer and all-cause mortality. Public Health Nutr. 2022;25(12):3390–400. https://pubmed.ncbi.nlm.nih.gov/34930509/
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Le Couteur DG, Solon-Biet SM, Cogger VC, et al. Branched chain amino acids, aging and age-related health. Ageing Res Rev. 2020;64:101198. https://pubmed.ncbi.nlm.nih.gov/33132154/
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Insulin resistance. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/22206-insulin-resistance. Updated December 16, 2021. Accessed December 26, 2022.; https://my.clevelandclinic.org/health/diseases/22206-insulin-resistance
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Zhang X, Li J, Zheng S, Luo Q, Zhou C, Wang C. Fasting insulin, insulin resistance, and risk of cardiovascular or all-cause mortality in non-diabetic adults: a meta-analysis. Biosci Rep. 2017;37(5):BSR20170947. https://pubmed.ncbi.nlm.nih.gov/28811358/
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Ju SY, Lee JY, Kim DH. Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly: a meta-analysis of prospective cohort studies. Medicine (Baltimore). 2017;96(45):e8491. https://pubmed.ncbi.nlm.nih.gov/29137039/
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Bishop CA, Machate T, Henning T, et al. Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle. Nutr Diabetes. 2022;12(1):1–9. https://pubmed.ncbi.nlm.nih.gov/35418570/
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Jang C, Oh SF, Wada S, et al. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016;22(4):421–6. https://pubmed.ncbi.nlm.nih.gov/26950361/
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Williams KJ, Wu X. Imbalanced insulin action in chronic over nutrition: clinical harm, molecular mechanisms, and a way forward. Atherosclerosis. 2016;247:225–82. https://pubmed.ncbi.nlm.nih.gov/26967715/
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Cummings NE, Williams EM, Kasza I, et al. Restoration of metabolic health by decreased consumption of branched-chain amino acids. J Physiol. 2018;596(4):623–45. https://pubmed.ncbi.nlm.nih.gov/29266268/
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Solon-Biet SM, Cogger VC, Pulpitel T, et al. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab. 2019;1(5):532–45. https://pubmed.ncbi.nlm.nih.gov/31656947/
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Nie C, He T, Zhang W, Zhang G, Ma X. Branched chain amino acids: beyond nutrition metabolism. Int J Mol Sci. 2018;19(4):954. https://pubmed.ncbi.nlm.nih.gov/29570613/
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Bishop CA, Machate T, Henning T, et al. Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle. Nutr Diabetes. 2022;12(1):1–9. https://pubmed.ncbi.nlm.nih.gov/35418570/
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Rhee EP, Ho JE, Chen MH, et al. A genome-wide association study of the human metabolome in a community-based cohort. Cell Metab. 2013;18(1):130–43. https://pubmed.ncbi.nlm.nih.gov/23823483/
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Lotta LA, Scott RA, Sharp SJ, et al. Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis. PLoS Med. 2016;13(11):e1002179. https://pubmed.ncbi.nlm.nih.gov/27898682/
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Mahendran Y, Jonsson A, Have CT, et al. Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels. Diabetologia. 2017;60(5):873–8. https://pubmed.ncbi.nlm.nih.gov/28184960/
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White PJ, Newgard CB. Branched-chain amino acids in disease. Science. 2019;363(6427):582–3. https://pubmed.ncbi.nlm.nih.gov/30733403/
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Okekunle AP, Zhang M, Wang Z, et al. Dietary branched-chain amino acids intake exhibited a different relationship with type 2 diabetes and obesity risk: a meta-analysis. Acta Diabetol. 2019;56(2):187–95. https://pubmed.ncbi.nlm.nih.gov/30413881/
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Ridaura VK, Faith JJ, Rey FE, et al. Cultured gut microbiota from twins discordant for obesity modulate adiposity and metabolic phenotypes in mice. Science. 2013;341(6150):1241214. https://pubmed.ncbi.nlm.nih.gov/24009397/
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Bachmann OP, Dahl DB, Brechtel K, et al. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes. 2001;50(11):2579–84. https://pubmed.ncbi.nlm.nih.gov/11679437/
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Arany Z, Neinast M. Branched chain amino acids in metabolic disease. Curr Diab Rep. 2018;18(10):76. https://pubmed.ncbi.nlm.nih.gov/30112615/
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Smith GI, Yoshino J, Stromsdorfer KL, et al. Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation. Diabetes. 2015;64(5):1555–63. https://pubmed.ncbi.nlm.nih.gov/25475435/
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Manco M, Bertuzzi A, Salinari S, et al. The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects. Br J Nutr. 2004;92(6):895–903. https://pubmed.ncbi.nlm.nih.gov/15613251/
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Fontana L, Cummings NE, Arriola Apelo SI, et al. Decreased consumption of branched-chain amino acids improves metabolic health. Cell Rep. 2016;16(2):520–30. https://pubmed.ncbi.nlm.nih.gov/27346343/
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Cummings NE, Williams EM, Kasza I, et al. Restoration of metabolic health by decreased consumption of branched-chain amino acids. J Physiol. 2018;596(4):623–45. https://pubmed.ncbi.nlm.nih.gov/29266268/
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Wolfe RR. Branched-chain amino acids and muscle protein synthesis in humans: myth or reality? J Int Soc Sports Nutr. 2017;14(1):30. https://pubmed.ncbi.nlm.nih.gov/28852372/
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Buse MG. In vivo effects of branched chain amino acids on muscle protein synthesis in fasted rats. Horm Metab Res. 1981;13(9):502–5. https://pubmed.ncbi.nlm.nih.gov/7298019/
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Louard RJ, Barrett EJ, Gelfand RA. Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man. Clin Sci (Lond). 1990;79(5):457–66. https://pubmed.ncbi.nlm.nih.gov/2174312/
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Louard RJ, Barrett EJ, Gelfand RA. Overnight branched-chain amino acid infusion causes sustained suppression of muscle proteolysis. Metabolism. 1995;44(4):424–9. https://pubmed.ncbi.nlm.nih.gov/7723664/
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Plotkin DL, Delcastillo K, Van Every DW, Tipton KD, Aragon AA, Schoenfeld BJ. Isolated leucine and branched-chain amino acid supplementation for enhancing muscular strength and hypertrophy: a narrative
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